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Effects of Pineapple Ceramide on Epidermal Function (1): An In Vitro Study

The epidermis forms the interface between the body and the external environment, serving essential physiological functions by preventing transepidermal water loss and protecting the body from environmental insults. However, these functions are compromised by intrinsic aging-related factors, including endocrine, nutritional, immunological, and oxidative changes, as well as by various environmental stressors. As a result, both skin barrier function and skin hydration decline.

Consequently, the skin becomes more susceptible to external stimuli, epidermal turnover is disrupted, and skin concerns such as dullness and roughness become more likely to occur.

Studies have demonstrated that pineapple ceramide enhances the expression of genes associated with skin barrier function and hydration in human epidermal keratinocytes, the predominant cell type of the epidermis.

In particular, pineapple ceramide has been shown to promote filaggrin expression, which is essential for the formation of the stratum corneum and maintenance of an effective skin barrier, while also upregulating aquaporin-3 (AQP3) expression, a key regulator of cellular water transport and skin hydration.

 

Functional Effects Targeting the Epidermis

Source：FOOD STYLE21

Supervisor

President
Born in Gunma Prefecture in 1965, he completed his doctoral studies at the Graduate School of Agricultural Science at Tokyo University of Agriculture (PhD), and served as a special research fellow at the Japan Society for the Promotion of Science, a part-time lecturer at Tokyo University of Agriculture, and an associate professor and professor at Takasaki University of Health and Welfare before becoming a professor at Tokyo University of Agriculture in April 2012. He is a professor at the same graduate school, and will be the president of Tokyo University of Agriculture in April 2021. He will be the chairman of Tokyo University of Agriculture in July 2023.

School he attended
April 1984 - March 1988 Graduated from the Department of Forestry (Forestry Science Course), Faculty of Agriculture, Tokyo University of Agriculture

Degrees he received
Tokyo University of Agriculture - Doctor of Forestry

Career history within the university
April 2012 - Ongoing Professor, Department of Forest Science, Faculty of Regional Environmental Science, Tokyo University of Agriculture
April 2016 - Ongoing Director, Food and Agriculture Museum, Tokyo University of Agriculture (Other organizations)
April 2021 - Ongoing President, Tokyo University of Agriculture

Academic societies and committees he has been affiliated with
April 1985 - Ongoing Japan Wood Research Society
June 1988 - Ongoing Japanese Mushroom Society
April 1995 - Ongoing Japanese Society of Inflammatory and Regenerative Medicine
April 1995 - Ongoing Japanese Society of Bioscience, Biotechnology, and Agricultural Chemistry
May 1995 - Ongoing Applied Pharmacology Research Society